In the last 20 years, various scientific Phlebology and Surgical publications have scientifically proven that genetics plays a part in chronic venous disease, varicose veins, spider vein formation over time as men and women age. In the following abstract, we can look forward to full genome studies to predict more accurately who will get vein disease based on genetics and therefore learn how to slow down the process with lifestyle, proper diagnosis, treatment modalities, and healthy vein practices including compression stockings, exercise, leg elevation and calf muscle pump activation, and FDA approved medicines. Annual maintenance has helped our existing patients for 20 years.
Recent sequencing of the human genome has opened up new areas of investigation for genetic aberrations responsible for the pathogenesis of many human diseases. To date, there have been no studies that have investigated the entire human genome for the genetic underpinnings of chronic venous insufficiency (CVI). Utilizing Gene Chip Arrays we analyzed the relative expression levels of more than 47,000 transcripts and variants and approximately 38,500 well-characterized genes from each of 20 patients (N (CVI)=10; N (Control Group)=10). Relative gene expression profiles significantly differed between patients with CVI and patients unaffected by CVI. Regulatory genes of mediators of the inflammatory reaction and collagen production were up-regulated and down-regulated, respectively in CVI patients. DNA microarray analysis also showed that relative gene expression of multiple genes which function remains to be elucidated was significantly different in CVI patients. Fundamental advancements in our knowledge of the human genome and understanding of the genetic basis of CVI represents an opportunity to develop new diagnostic, prognostic, preventive and therapeutic modalities in the management of CVI.
Come in for a free consult to see a video and learn about diagnosis with specific venous ultrasound techniques, healthy vein practices while you wait for treatments, compression stockings, and new FDA vein treatments: 480775-8460 @morrisonvein.com
“CHRONIC VENOUS INSUFFICIENCY (CVI) is one of the most common vascular diseases in the developed world and is a major contributor to psychosocial morbidity.” And one of the worst outcomes of venous disease is leg ulcers, esp for patients over 65- up to 4% of the population! Compression bandaging is the most recognized therapy but due to lack of education of the healthcare professionals regarding application and other treatment modalities, lack of patient funds, poor insurance reimbursement for stockings and bandaging- patients suffer for at least a year or up to 10 years needlessly.
Ross K Smith and Jonathan Golledge wrote a paper ( Phlebology 2014 Vol 29 (9) 570-579) on a review of circulatory markers in CVI and their abstract and paper to follow shows providers could evaluate patients levels of estradiol, homocysteine and vascular growth factors that were most consistently associated with primary chronic venous insufficiency.
Circulatory markers studies can improve pathogenic understanding, increase prognostic understanding and enhance diagnostic and treatment modalities.
Early recognition of vein disease with comprehensive diagnostic evaluation and in-office minimally invasive vein treatments: revolutionary glue ablations, radiofrequency or laser ablations and ultrasound guided chemical ablations of ” faulty valve- diseased” saphenous veins, accessory veins, pudendal veins, and even pelvic vein disorders can prevent the road to leg ulcers, DVTs, and varicose vein disease disorders.
Schedule a vein screening and learn about vein disease from Morrison Vein Institute.
We have been dedicated to vein disease for 20 years.